Specialist/Senior Specialist Pharmacometrician - Translational and Clin Dev

Specialist/Senior Specialist Pharmacometrician - Translational and Clin Dev Ascendis Pharma Hellerup, Denmark Description: Are you passionate about pharmacometrics and model-informed drug development? Do you have experience with translational and clinical population PK/PD modeling and support of regulatory submissions? If so, now is your chance to join Ascendis Pharma as our new Specialist/Senior Specialist Pharmacometrician. We are looking for a hands-on pharmacometrician who combines scientific excellence with strategic thinking and wants broad ownership across programs. We are seeking an experienced hands-on Specialist/Senior Specialist Pharmacometrician who can address complex development questions and translate quantitative insights into actionable recommendations. You will apply model-informed drug development in rare diseases, where quantitative methods can directly inform trial design, dose selection, and evidence generation in small patient populations. You will gain exposure across translational and development stages and contribute to projects throughout the portfolio, providing broad visibility and influence within the company. Your key responsibilities will be to: Develop model-informed drug development strategies for translational and clinical-stage projects and ensure optimal use of pharmacometric methods to inform trial and program design. Shape regulatory strategy and represent pharmacometrics in global health authority interactions. Inform dose selection, trial design, regulatory strategy, and lifecycle decisions through population PK/PD modeling, simulation, exposure response analysis, and quantitative benefit risk assessment. Translate quantitative results into clear recommendations to project teams, senior management, health authorities, external partners or organizations. Plan, document and report pharmacometric analyses in accordance with internal quality standards and global regulatory submission requirements. Strengthen departmental methods, standards and capabilities through peer reviews, knowledge sharing, and continued development of the department s modeling and reporting environment. Qualifications and Skills: You hold a PhD, MSc, or equivalent qualification in pharmacometrics, pharmaceutical sciences, pharmacokinetics, mathematics, engineering, or another relevant quantitative discipline. You have relevant experience with PK/PD modeling and model-informed drug development. Furthermore, you have: Hands-on experience with NONMEM and R applied to population PK/PD model development, simulation, and model-informed drug development. Strong programming skills and technical expertise to organize, perform, document, and report pharmacometric analyses to submission standard. Experience with translational and clinical-stage analyses, including population PK, PK/PD, exposure-response, dose selection, and trial-design questions. Additional experience that would be an advantage: Industrial experience supporting regulatory interactions or submissions, including knowledge of relevant FDA, EMA, and ICH expectations for pharmacometric analyses. Familiarity with LaTeX, Git and reproducible reporting workflows, or experience applying machine learning, artificial intelligence, or automation to pharmacometric workflows. Key competencies: You are a strong team player, analytical, and have a can-do attitude. You possess an entrepreneurial mindset and can thrive in an informal, open environment where innovation and change are key. You communicate complex quantitative findings clearly, work effectively across disciplines, and balance analytical detail with broader development objectives. You combine a strong quantitative background with biological and clinical understanding and collaborate effectively with scientists, clinicians, regulatory colleagues, and external partners. Your ability to share knowledge and contribute to common goals will be valued among colleagues. Apply Now