Postdoctoral Fellow in In Vitro/Ex Vivo ADME Liquid Biopsy

Postdoctoral Fellow in In Vitro/Ex Vivo ADME Liquid Biopsy Servier Gif-sur-Yvette, France Are you a fast-learning scientist passionate about optimizing clinical drug trials through the investigation of endogenous biomarkers ? We are seeking a Scientist to join our R&D organization. In this role, you will develop robust protocols to extract liver-derived extracellular vesicles (EVs) from culture media and human plasma and apply MultiOMICS (Proteomics and Transcriptomics) to monitor CYP450 and drug transporter induction/inhibition. Your work will reduce reliance on dedicated clinical DDI studies and feed into our global DDI monitoring strategy throughout clinical development. Responsibilities Design and conduct experiments with primary human hepatocytes, relevant cell lines, and human samples to set up, test, and optimize liver-derived EV isolation/enrichment protocols Evaluate the reliability of EV-based readouts to assess xenobiotic impacts on ADME protein expression (CYP450 and drug transporters induction/inhibition) Optimize sample preparation to maximize data yield from minimal plasma volumes Perform quantitative studies of global protein and gene expression in extracted EVs and monitor induction effects Work transversally with scientists across R&D to execute experiments and generate/analyze proteomics and transcriptomics datasets Communicate results internally (presentations/posters) and externally (peer-reviewed journals, posters, conferences), where applicable Contribute to general lab activities, including mentoring undergraduate/graduate students and participating in science outreach, where applicable Profile PhD in biochemistry, molecular biology, cell biology, or equivalent Proven experience with extracellular vesicle extraction and analysis Expertise in sample preparation and core biochemical methods (WB, ELISA, qPCR) Proficiency in proteomics, genomics, and transcriptomics is valued Some bioinformatics experience for protein identification and gene expression analysis Knowledge of pharmacokinetics and cell culture is a plus (not required) Ability to mentor internship- or technician-level collaborators Team-oriented, results-driven, curious, and autonomous Strong communication skills with demonstrated experience writing and publishing in international peer-reviewed journals Apply Now