Senior Scientist, LC-MS Proteomics

Senior Scientist, LC-MS Proteomics VIB Ghent, Belgium Your Role You independently operate state-of-the-art high-resolution LC-MS/MS platforms, such as Orbitrap and/or timsTOF instruments, coupled to nanoLC and/or microLC systems; You develop, optimize, implement and execute LC-MS/MS methods, including LC gradients, MS acquisition parameters and full analytical workflows; You take ownership of instrument performance and quality control, including tuning, calibration, routine maintenanceand troubleshooting, in order toproactively intervene withperformance deterioration before it impacts research projects; You carefully document experimental procedures, instrument performance, data and results, and work according to applicable SOPs and quality guidelines; You contribute to the continuous improvement of existing workflows and to the development and implementation of state-of-the-art LC-MS and proteomics applications; You stay up-to-date with emerging technologies and developments in LC-MS driven proteomics. Your qualifications Essential BSc, MSc or PhD in analytical chemistry, industrial sciences, biochemistry, biotechnology, biomedical sciences, molecular biology, or a related field; At least 5 years of relevant hands-on LC-MS/MS experience; Strong practical experience with high-resolution mass spectrometry platforms, such as Orbitrap and/or timsTOF, coupled to nanoLC and/or microLC systems; Demonstrated ability to independently operate LC-MS/MS instrumentation, including tuning, calibration, acquisition method setup, routine maintenance, monitor instrument performance and troubleshooting; Experience in LC-MS/MS method development and optimization, including LC gradients, MS acquisition parameters and complete analytical workflows; Basic working knowledge of proteomics data analysis and search-engine tools, including protein/peptide identification, quantification, quality control and interpretation. Desirable Practical experience with proteomics sample preparation; Experience with post-translational modification (PTM) analysis; Experience with multiplexed quantitative proteomics approaches; Experience with intact protein measurements and characterization; Experience with targeted proteomics; Knowledge of statistical analysis and quantitative interpretation of proteomics data; Experience working in a core facility or service-oriented scientific environment. Key personal characteristics Hands-on, proactive and solution-driven; Strong analytical and problem-solving skills; Meticulous, organized and committed to delivering reliable, high-quality results; Scientific curiosity and eagerness to learn and implement new technologies; Independent team player; Service-oriented mindset; Comfortable working in an international setting: fluent in English. Apply Now