Scientist II - Clinical Laboratories

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about. **Job Overview** ---------------- **Scientist II - Clinical Laboratories** As a **Scientist II** for our **Clinical Laboratories Scientist** team at the **Senneville** location, you will play a key role in evaluating the potential effects of investigational drugs on platelet function, coagulation, and overall hemostatic balance using state-of-the-art in vitro and ex vivo methodologies. This position offers the opportunity to work within a multidisciplinary team of toxicologists, clinical pathologists, and translational scientists supporting both regulatory and research studies. In this role, **primary responsibilities** include: * Design, develop, validate, and conduct studies assessing drug-induced effects on hemostasis; * Perform and interpret assays evaluating: + Platelet activation and physiology; + Platelet aggregation and secretion; + Platelet adhesion under flow conditions; + Coagulation cascade and coagulation factor activity; + Global hemostasis assessments. * Develop and optimize platelet-function methodologies using: + Light transmission and impedance aggregometry; + Microfluidic and vascular-flow systems; + Whole blood and plasma-based assays. * Characterize potential toxicological effects of novel therapeutics on platelet and coagulation pathways; * Analyze, interpret, and communicate complex scientific data; * Collaborate with multidisciplinary teams including toxicology, pathology and immunology; * Contribute to scientific innovation, assay development, and implementation of emerging technologies in hemostasis research; * Ensure compliance with applicable quality standards, SOPs, and regulatory requirements. **Key Elements** ---------------- We are looking for the **following qualifications** for this role: * Holder of a Master or a PhD in Hematology, Vascular Biology, Cell Biology, Pharmacology, Biochemistry, or a related scientific discipline; * Strong scientific background in platelet biology, platelet physiology, and hemostasis; * Hands-on experience with: + Platelet aggregation assays; + Microfluidic systems and flow-based thrombosis models; + Coagulation assays and coagulation factor testing; * Demonstrated ability to independently design and execute experimental studies; * Strong data analysis and scientific writing skills; * Track record of scientific publications in relevant fields; * Excellent verbal and written communication skills. **Role Specific Information:** * Location: 22022 route Transcanadienne, S